Serious drug risks associated
with acid reflux medications.

Stomach acid plays a vital role in your body. Anti-reflux medications essentially turn off the production of acid in your stomach, potentially throwing off the natural balance of your body. As the list of side effects linked to these drugs continues to grow in length and severity, it is important to understand the risks and take control of your treatment options.

FDA on PPIs: 14 days max,
three times per year.

Since their introduction to the market in the 1980’s, proton pump inhibitors (PPIs) have become the mainstay of acid reflux treatment. Due to their long-term side effects, FDA guidelines state that PPI medications (OTC) should only be used for 14-days, 3x a year. That’s it. Many patients have been taking these medications for years, even decades. How long have you been taking PPIs?

PPIs come in many forms:
• Prilosec (Omeprazole)
• Prevacid (Lansoprazole)
• Dexilant (Dexlansoprazole)
• Nexium (Esomeprazole)
• Protonix (Pantoprazole)
• AcipHex (Rabeprazole)

PPI medications for reflux have been
linked to the following side effects:

Dementia and Alzheimer’s.

44% increased risk of dementia and Alzheimer’s disease in patients over 75 years of age with a slightly higher risk to men over women1.

Heart disease.

20% increased risk of heart attacks among all adult PPI users, in addition to a 2x greater risk of PPI users suffering from a major adverse cardiovascular event vs. non-users2.

Chronic kidney disease.

46% increased risk of developing chronic kidney disease (CKD) for those taking twice-daily PPIs as compared to a 15% increased risk for once daily users3.

Hip, spine and wrist

2x increased risk of suffering from a hip, wrist or spine fracture in patients over 50 years of age with the greatest risk being for those who take high doses of PPIs for one year or longer4.

FDA Drug Safety Announcement


42% increased risk of developing community-acquired pneumonia with greater risks associated with those patients taking higher dosages of PPIs5.

1. Gomm W, von Holt K, Thomé F, et al. Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis. JAMA Neurol. Published online February 15, 2016. doi:10.1001/jamaneurol.2015.4791.
2. Shah NH, LePenduP, Bauer-Mehren A, GhebremariamYT, Iyer SV, et al. (2015) Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. PLoS ONE 10(6): e0124653. doi: 10.1371/journal.pone.0124653.
3. Lazarus B, Chen Y, Wilson FP, et al. Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease. JAMA Intern Med. 2016;176(2):238-246. doi:10.1001/jamainternmed.2015.7193.
4. /PostmarketDrugSafetyInformationforPatientsandProviders/ ucm213206.htm
5. Laheij RF, SturkenboomMM, Hassing R, Dieleman J, Stricker BC, Jansen JJ. Risk of Community-Acquired Pneumonia and Use of Gastric Acid–Suppressive Drugs. JAMA. 2004;292(16):1955-1960. doi:10.1001/jama.292.16.1955.

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